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Simmons Limited Jersey , Aug. 23 (Xinhua) -- Researchers at
the University ofMichigan (UM) recently found that activating the amygdala
portionof the brain can intensify one's motivation to consume cocaine farbeyond
ordinary drug levels.
"This would suggest that the amygdala plays a key role in drugaddiction,"
said Shelley Warlow, a UM psychology graduate studentand the study's lead
Researchers implanted rats with a catheter that allowed them toearn doses of
cocaine by poking their noses into small holes in thewall.
Whenever rats poke their nose into one particular hole to earnintravenous
cocaine, a laser light would also painlessly activatethe neurons in the central
amygdala at the same time.
Poking their nose into a different hole earned
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When being able to freely choose between those two cocainerewards, rats
focused only on the port that earned cocaine togetherwith amygdala-activating
laser, consumed much more cocaine thanrats without amygdala activation, and
avidly nibbled around thelaser-cocaine hole as though seeking more.
Rats with amygdala activation were also willing to work almostthree times
harder for the cocaine Jake Butt
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Rats appeared to be indifferent to amygdala laser activation.The amygdala
activation only intensified motivation when cocainewas present.
By contrast, when the researchers temporarily inactivated theamygdala using
a painless drug infusion, rats completely stoppedresponding for cocaine
"Understanding brain areas and the mechanisms involved in thisintense
motivation will be important in developing treatments foraddiction and other
compulsive disorders," Warlow said. Enditem
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